Rare combination of ovarian tumors found in one patient: Case report
A new case report was published in Oncoscience's Volume 12 on March 31, 2025, titled "Cystadenofibroma and contralateral collision lesions: A unique ovarian case report."
Authored by Dr. Naina Kumar and colleagues from the All India Institute of Medical Sciences, the report presents a highly unusual case involving two different types of benign ovarian tumors in a single patient. One ovary contained a rare serous cystadenofibroma, while the other had a collision tumor—two distinct cyst types, serous and mucinous, growing side by side without mixing. This specific tumor combination has been reported in very few cases.
The patient was a 41-year-old woman who came to the hospital with lower abdominal pain and swelling that had persisted for several months. Imaging revealed large cystic growths in both ovaries. To rule out malignancy and address the condition, clinicians performed surgery to remove her uterus, both ovaries, and fallopian tubes. Laboratory analysis after surgery confirmed that the tumors were non-cancerous, and the patient recovered well without complications.
Serous cystadenofibromas are rare, accounting for only about 1.7% of benign ovarian tumors. They are often discovered by chance during routine gynecological exams and usually do not cause symptoms. Collision tumors are even rarer and involve two different types of tumors occurring in the same organ without blending. Despite being benign, their size and complex appearance on imaging can closely resemble cancer, which makes diagnosis before surgery particularly challenging.
This case underscores the importance of thorough preoperative evaluation. Imaging studies, tumor marker analysis, and clinical examination all play a vital role in avoiding misdiagnosis and unnecessary treatment. In this instance, the surgical team was able to accurately assess the tumor characteristics and proceed with appropriate care.
“Accurate preoperative diagnosis is critical for effective treatment planning and avoiding unnecessary interventions that could pose additional risks to the patient.”
Because both tumors were benign, surgery alone was an effective solution, and no further treatment was required. The case adds valuable knowledge to the limited number of documented reports on rare ovarian tumor combinations and contributes new insight to the study of ovarian tumors. It also emphasizes the need for personalized evaluation of each ovarian mass, especially when imaging findings are unclear.
By sharing this unusual case, the authors emphasize how crucial it is to diagnose early, confirm with histopathology, and provide customized surgical treatment to achieve the best results for patients with complex ovarian tumors.
Reference:
Kumar N, Rath A, Setty A, Rathod PT, Aparna J. Cystadenofibroma and contralateral collision lesions: A unique ovarian case report. Oncoscience. 2025 Mar 31;12:26-33. doi: 10.18632/oncoscience.
